Course

Unit 1

Introduction to disease pathogenesis, clinical terminologies, concept of prognosis, evidence-based treatment approach, bench-to-bedside approach in medicine, and introduction to a holistic approach in treating diseases

Unit 2

The process of growth, differentiation and cell death and its molecular organization in cellular homeostasis and diseases such as cancer, neurodegenerative diseases and diabetes. Significance of molecular changes in controlling a normal homeostasis condition compared to disease.

Unit 3

Pathological changes in diseases such as cancer, neurodegenerative diseases, autoimmune diseases and diabetes. The role of molecules and molecular changes in the pathological manifestation of disease.

Unit 4

Significance of environmental chemicals in modifying normal homeostasis and leading to pathological changes at molecular level by controlling different signaling mechanisms. Significance of epidemiology, etiology in pathogenesis of diseases

Unit 5

Inflammation in normal and pathological state. Molecular mechanisms driving the immunopathology in cancer, neurodegenerative diseases, autoimmune diseases and diabetes. Interdependence of molecular pathways in controlling homeostasis and disease pathology.

#BBD0E0

Unit 6

How the molecular changes can be targeted to reverse the pathology and the contribution of drugs in this respect cancer, neurodegenerative diseases, autoimmune diseases and diabetes

Unit 7

DNA modifications and mutations in diseases and its significance in the pathology associated with cancer, neurodegenerative diseases, autoimmune diseases and diabetes. Role of environment in (lifestyle) in modifying DNA and the molecular landscape associated with homeostasis and disease in cancer, neurodegenerative diseases, autoimmune diseases and diabetes

Pre-requisites: Basic understanding of biology and biochemistry

Total number of classes: 45

Course Outcome

• To demonstrate ability to approach a scientific report in a systematic manner
• To be able to identify scientific hypothesis and understand the rationale behind the research approach in a scientific report
• Be able to summarize disease pathogenesis and connect it to clinical signs and symptoms associated with the particular disease
• Be able to work with team and put together in depth information related to disease mechanism at the cellular and molecular level, treatment options and current developments in the field

Robbins Basic Pathology, 9th edition, Kumar, Abbas, Fausto and Mitchell; Saunders, Publication, ISBN-13: 978-1437717815. ]

Selected research articles will be provided before each class