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Course Detail

Course Name Regenerative Medicine & Tissue Engineering
Course Code 24MMD543
Program M. Sc. Molecular Medicine(MLM)
Semester 2
Credits 3
Campus Faridabad, Kochi

Syllabus

Unit 1

Lectures

Biologic and Molecular Basis for Regenerative Medicine:Current perspectives in Regenerative Medicine; Types of Tissues; Molecular organisation of cells; Extracellular Matrix; Cell-extracellular matrix interactions

Unit 2

Lectures

Cellular aspect of Regenerative Medicine: Stem cells and progenitors; Types of stem cells, Embryonic stem cells, induced pluripotent stem cells, Mesenchymal stem cells, Hematopoietic stem cells, Adult stem cells

Unit 3

Lectures

Different Stages of Tissue Regeneration: Basic cell structure and functions; Tissue organisation and functions; Organ structure and functions, Scar and Regeneration; Different stages of regeneration – Hemostasis, Inflammation, Proliferation, Angiogenesis, Remodelling; Case studies – Skin regeneration, Bone regeneration, Liver regeneration.

Unit 4

Lectures

Tissue Engineering: Relevance of tissue engineering; Triad of Tissue engineering – Scaffolds Types (Ceramics, Polymers, Composites Biomimetic scaffold); Cells, Growth factors; Case Studies: Ectoderm derived tissues (Nerve tissue, Cornea), Endoderm derived tissues (Liver, Pancreas), Mesoderm (Bone, Cartilage, Muscle, blood vessels, ligament, Tendon). Recent advances in biofabrication; 3D bioprinting

Objectives and Outcomes

Pre-requisites: Undergraduate level biology, biotechnology and physiology
Course code:
Course name: REGENERATIVE MEDICINE & TISSUE ENGINEERING
Credits: 3
Pre-requisites: Undergraduate level basic physics, chemistry and biology
Total number of classes: 45

COURSE OUTCOMES:

Upon successful completion, students will have the

CO1. Understanding on the molecules and signalling pathways that regulate epithelial and mesenchymal states of tissues and cell-extracellular matrix interactions

CO2. Knowledge on the various types and sources of stem cells and their role in tissue growth, repair and regeneration

CO3. Knowledge on the inherent regenerative mechanisms in human body

CO4. Understanding on the fundamental aspects of tissue engineering and their application in developing various tissues. 

Program Outcome 

PO1: Bioscience Knowledge

PO2: Problem Analysis

PO3: Design/Development of Solutions

PO4: Conduct Investigations of complex problems

PO5: Modern tools usage

PO6: Bioscientist and Society

PO7: Environment and Sustainability

PO8: Ethics

PO9: Individual & Team work

PO10: Communication

PO11: Project management & Finance

PO12: Lifelong learning

3 = High Affinity, 2 = Medium Affinity, 1 = Low Affinity, – = No Affinity

C

PO1

PO2

PO3

PO4

PO5

PO6

PO7

PO8

PO9

PO10

PO11

PO12

C O

CO 1

3

1

1

–

1

1

–

–

–

–

–

2

CO 2

3

1

1

–

1

1

–

3

1

–

–

2

CO 3

3

1

2

3

1

1

–

1

1

–

–

2

CO 4

3

1

3

3

3

1

–

1

1

–

–

2

Program Specific Outcomes. (PSO)

PSO 1 – Biochemical organization and cellular complexity in function

PSO 2 – Biomolecules in Medicine

PSO 3 – Molecular basis of disease

PSO 4 – Molecular technology in diagnosis and therapy

PSO 5 – Cellular based approaches in diagnosis and therapy

PSO 6 – Microorganisms in Medicine

PSO 7 – Nanoscale entities and its significance in Medicine

PSO 8 – Tissue architecture engineering in Medicine

PSO 9 – Compounds as drugs and its efficacy

PSO 10 – Bioinformatics and biological data use

C

PO1

PO2

PO3

PO4

PO5

PO6

PO7

PO8

PO9

PO10

C O

CO 1

3

1

–

–

3

–

1

3

–

–

CO 2

–

2

–

–

3

–

–

3

–

–

CO 3

2

2

–

–

3

–

–

3

–

–

CO 4

2

2

–

–

3

–

2

3

3

–

Evaluation Pattern: 50+50 = 100

Internal Assessment – 50% 

Periodical 1 

Exam 

20% 

Periodical 2 

Exam 

20% 

Continuous Assessment 

Assignment/Test/Quiz 

10% 

50%

End Semester Examination- 50% 

Theory Exam 

50% 

50%

Total

100%

Text Books / References

Text Book

Principles of Regenerative Medicine, Anthony Atala, Robert Lanza James, Thomson Robert Nerem, 2nd Edition, Elsevier -2010

References:

  1. Ying Deng and Jordan Kuiper, Functional 3D Tissue Engineering Scaffolds: Materials, Technologies, and Applications (Woodhead Publishing Series in Biomaterials), 2017
  2. Cato T. Laurencin, Lakshmi S. Nair. Nanotechnology and Regenerative Engineering: The Scaffold, Second Edition, CRC Press 2017

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