Course

Unit 1

Topical drug delivery to the posterior segment of the eye : Diseases which require this delivery, challenges, development, and evaluation of innovative drug delivery

systems for ocular posterior segment delivery. (5 hours)

Unit 2

Controlled Release Nanomedicines (CRNMs) for cancer and cardiovascular diseases. Past, present and future of nanomedicines. Nanomedicines for oral and parenteral applications. Cancer nanomedicines, cardiovascular

nanomedicines current status and future prospects. (5 hours)

Unit 3

Oral Drug Developability: Evaluation of a drug candidate’s potential to become a successful oral therapeutic product. Core concepts and theoretical foundations. Solutions to common developability challenges. Case studies and real-

world examples of amorphous solid dispersions. (5 hours)

Unit 4

Respiratory Drug Delivery, Mechanisms of Action: Local vs.

Systemic Effects, Dry powder inhalation and Inhalation devices, Barriers for pulmonary drug delivery, Various

pulmonary drug delivery systems, Formulation challenges. (5 hours)

Unit 5

Introduction to Brain Drug Delivery: Traditional & novel brain drug delivery systems, Advanced strategies to overcome the Blood blood-brain barrier, Current research & Clinical trials (5 hours)

(including case studies).

Unit 6

Introduction, definition, and history of theranostics. Applications of theranostic in Cancer (e.g., imaging-guided surgery, radioimmunotherapy) and neurological disorders (e.g., brain tumors). A discussion on noninvasive bioimaging techniques such as magnetic resonance imaging (MRI), NIR fluorescence

imaging and photoacoustic imaging.(5 hours)

This course aims at introducing the students to research in advanced technologies in drug delivery related to various acute and chronic diseases. It explores latest advancements and cutting-edge technologies in drug delivery systems, providing in-depth knowledge necessary for developing innovative therapeutic solutions. This subject also deals with combination products and drug-device-based combinations that extensively use biomaterials for long-term drug delivery requirements. It provides various perspectives of theranostics. Research related to drug delivery approaches, personalized to disease conditions, design and development of delivery systems is also emphasized.

COURSE LEARNING OUTCOMES

Upon successful completion of the course, the student shall be able to get,

KNOWLEDGE:

(K1) Articulate the need of drug delivery research for the treatment of posterior segment of eye, cancer and cardiovascular diseases.

(K2) Examine the principles of development of innovative drug delivery solutions, Controlled Release Nanomedicines, Amorphous solid dispersions, Respiratory drug delivery systems, Brain drug delivery systems, and Theranostic systems.

(K3) Organize various aspects of clinical/technological unmet needs for personalized drug delivery applications.

(K4) Prepare drug delivery strategies for affordable and accessible medicines.

(K5) Appraise the formulation development principles for the development of modified delivery system.

(K6) Assess the complexity of emerging pharmaceuticals from clinical and industrial perspectives.

SKILL:

(S1) Draft a clinically identified unmet need for drug delivery strategies.

(S2) Categorize various factors governing drug delivery for novel drug delivery systems. (S3) Validate a pharmaceutical layout concerning required PK and PD studies.

(S4) Write the objectives of the proposed drug delivery project.

(S5) Adapt suitable characterization and evaluation techniques for the study. (S6) Explain suitable ex vivo permeability studies.

ATTITUDE:

(A1) Appreciate the research in drug delivery science. (A2) Embrace the possibilities of research.

(A3) Foster critical thinking to develop a science-based research project. (A4) Ensure teamwork in research.

(A5) Cultivate data integrity in research for drawing appropriate conclusions. (A6) Adapt well in multidisciplinary research team.

Reference Books

1. P. Sharma, K. Kaladhar, Nanomedicine in Translational Research, Status and Future Challenges, Ist Edn., Elsevier, 2024.
2. Jayakumar, S. V. Nair, Biomedical applications of polymeric nanofibers, Ist Edn., Elsevier, 2012.
3. O. Williams, D. A. Davis Jr., D. A. Miller, Formulating Poorly Water Soluble Drugs. Ist Edn., 2022.
4. P. Shah, U. Banakar, S. B. Tiwari. Desk Book of Pharmaceutical Dissolution Science and Applications., 2nd Edn., SPDS, India, 2022.
5. Y Chien, Novel Drug Delivery Systems, 2^nd edition, revised and expanded, Marcel Dekker, Inc., New York, 1992.

JOURNALS:

1. Journal of Controlled Release (Elsevier).
2. Advanced Drug Delivery Reviews (Elsevier).
3. Biomaterials (Elsevier).
4. Indian Journal of Pharmaceutical Sciences (IPA)
5. Journal of Biomaterial Applications (SAGE).
6. Drug Development and Industrial Pharmacy (Taylor and Francis).
7. Trends in Biomaterials and Artificial Organs India, (SBAOI).

Assignments

1. Drug eluting contact
2. Controlled release nanomedicine strategy for TME
3. Survey of polymers used for solid dispersions in
4. Comparative analysis of dry powder inhalation technology and advancements in the
5. Identify specific drugs or therapeutic agents successfully utilized novel drug delivery systems for brain delivery.
6. Discuss the application of NIR flurophores in robotic surgery by Da Vanci firefly