Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Colloids and Surfaces B: Biointerfaces, Elsevier
Source : Colloids and Surfaces B: Biointerfaces, Elsevier, Volume 114, p.209-217 (2014)
Keywords : 1 (3 dimethylaminopropyl) 3 ethylcarbodiimide, Acrylic Resins, Animals, apoptosis, article, breast cancer, Breast cancer cells, Breast Neoplasms
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2014
Abstract : 5-FU/Megestrol acetate loaded fibrinogen-graft-PNIPAAm Nanogels (5-FU/Meg-fib-graft-PNIPAAm NGs) were prepared for thermo responsive drug delivery toward α5β1-integrins expressing breast cancer cells in vitro (MCF-7 cells). The 60-100nm sized fib-graft-PNIPAAm nanogels (LCST=35°C) were prepared by CaCl2 cross-linker. 5-FU/Meg-fib-graft-PNIPAAm NGs showed particle size of 165-195nm size. The drug loading efficiency with 5-FU was 60% and 70% for Meg. Drug release was greater above the lower critical solution temperature (LCST). Above LCST, drug release system triggers apopotosis and enhance toxicity to MCF-7 cells when compared to the equivalent dose of the free drug. This effect was due to the greater uptake of the drug by MCF-7 cells. 5-FU/Meg-fib-graft-PNIPAAm NGs is portrayed here as a new combinatorial thermo-responsive drug delivery agent for breast cancer therapy
Cite this Research Publication : N. S. Rejinold, Baby, T., Chennazhi, K. P., and Dr. Jayakumar Rangasamy, “Dual Drug Encapsulated Thermo-sensitive Fibrinogen-graft-poly (N-isopropyl acrylamide) Nanogels for Breast Cancer Therapy”, Colloids and Surfaces B: Biointerfaces, vol. 114, pp. 209-217, 2014.