Publication

Abstract : Alcohol consumption has been associated with alcoholic hepatitis, fatty infiltrataion of liver, accelerated progression of liver disease, a higher frequence of cirrhosis, with significant incidents of hepatocellular carcinoma, and death. There is no approved therapeutics intervention for alcoholic liver disease; hwever early stages are treatable. Ursodeoxycholic acid(ursidol) is a non-toxic cholestatic liver disorders.In the present study efficiacy of ursodiol to treat ethanol induced oxidatitive stress was monitored. It was found that ethanol-induced oxidative stess could be marginally prevented by ursodeoxycholic acid supplementation. Absentation from alcohol improved hepatic regeneration.