Publication

Abstract : Aluminum and alcohol, both are well-accepted neurotoxin. The plausible mechanisms for their neurotoxicityare also common. Therefore, the effect of ethanol on aluminum induced biochemical changes in rat brain isbeing studied. In the present study, ethanol exposure significantly affected the aluminum and protein contentof brain. The activities of acid phosphatase and alkaline phosphatase were also changed. Aluminum exposure,on the other hand, contributed significantly in the alterations of aluminum content, acid phosphatase activityand aspartate aminotransferase activity. Though ethanol co-exposure significantly influenced the aluminumload of brain, the interactions of these two neurotoxins were found to be significant only in case of acidphosphatase activity of brain. Therefore, it can be suggested that general neurotoxicity produced by aluminumis not modified by ethanol. However, the aluminum load caused by aluminum exposure, may be influenced byethanol co-exposure