Programs
- M. Tech. in Automotive Engineering -
- Fellowship In Interventional Pulmonology and Pulmonary Critical care - Fellowship
Publication Type : Journal Article
Publisher : The Journal of Maternal-Fetal & Neonatal Medicine
Source : The Journal of Maternal-Fetal & Neonatal Medicine, 2020 Oct 18:1-7. DOI: 10.1080/14767058.2020.1828333. Epub Ahead of print. PMID: 33070681.
Url : https://www.tandfonline.com/doi/full/10.1080/14767058.2020.1828333
Campus : Kochi
School : School of Medicine
Department : Paediatric Cardiology
Year : 2020
Abstract : Objective To describe maternal and fetal outcomes and N Terminal pro-brain natriuretic peptide (NT-proBNP) trends in pregnancy with pulmonary arterial hypertension (PAH). Methods The medical records of all pregnant women with PAH referred to Pulmonary Hypertension Clinic were retrospectively reviewed and analyzed. Results We identified 35 pregnancies in 22 women (mean age 27.9 ± 4.7 years, mean weight 50.6 ± 8.1 kg). The diagnoses were Eisenmenger syndrome (16, 72.7%), postoperative residual PAH (3, 13.6%), idiopathic PAH (2, 9.1%), and one (4.5%) had systemic lupus erythematosus. About 23 babies (65.7%) were born alive, gestational age of 35.1 ± 2.9 weeks, 47.8% at term, with a birth weight of 2.1 ± 0.8 kg. There was an elevation of NT-proBNP in the initial 72 h postdelivery (median 138 pg/ml, IQR 112-561). Those with a persistent rise beyond 72 h (median 686 pg/ml, IQR 370-3691) had prolonged recovery postpartum (median postdelivery hospital stay 18 days, IQR 12–22) reflecting continued right ventricular stress and maladaptation. There was single maternal mortality (4.5%). Conclusions Maternal and fetal outcomes of pregnancy associated with PAH are better with strict surveillance and multidisciplinary team effort. Postpartum period remains the most vulnerable time. NT-proBNP trends during this period may be a promising objective monitoring tool in identifying at-risk subsets thus improving outcomes.
Cite this Research Publication : Prasad CS, Kumar S, Sumathy S, Kunjukutty R, Puthenveettil N, Sen AC, Sivabalakrishnan JB, Kumar RK., "Pregnancy and pulmonary arterial hypertension-improving surveillance and outcomes with multidisciplinary care and N terminal pro-brain natriuretic peptide trends," The Journal of Maternal-Fetal & Neonatal Medicine, 2020 Oct 18:1-7. DOI: 10.1080/14767058.2020.1828333. Epub Ahead of print. PMID: 33070681.