Publication

Abstract : We studied effect of exogenous ascorbic acid, α-tocopherol,lecithin and L-ornithine-L-aspartate on serum lipids and proteins inexperimental hepatotoxic Wistar rats. Eleven groups (n = 6) of animals were used. Hepatotoxicity was induced by administering ethanol (1.6g/kg/day) for 28 days. Both preventive and curative options were studied.Percentage increase in body weight was significantly lower in ethanol treated rats Ethanol significantly (Plt;0.05) increased cholesterol, triglycerides and LDL, and decreased protein, albumin and A: G ratio in serum. Ascorbic acid, α-tocopherol, lecithin and L-ornithine-L-aspartate exhibited an ability to counteract the alcohol-induced changes in the body weight and biochemical parameters in preventive and therapeutic models in varying degree. Antioxidants showed better effect.