Programs
- M. Tech. in Automotive Engineering -
- Fellowship In Interventional Pulmonology and Pulmonary Critical care - Fellowship
Publication Type : Journal Article
Publisher : Journal of Chemical Physics (Communication)
Source : Journal of Chemical Physics (Communication),152, 111102, 2020
Url : https://pubs.aip.org/aip/jcp/article/152/11/111102/198403/The-guiding-role-of-dissipation-in-kinetic
Campus : Coimbatore
School : School of Artificial Intelligence
Center : Center for Computational Engineering and Networking
Year : 2020
Abstract : Major biological polymerization processes achieve remarkable accuracy while operating out of thermodynamic equilibrium by utilizing the mechanism known as kinetic proofreading. Here, we study the interplay of the thermodynamic and kinetic aspects of proofreading by exploring the dissipation and catalytic rate, respectively, under the realistic constraint of fixed chemical potential difference. Theoretical analyses reveal no-monotonic variations of the catalytic rate and total entropy production rate (EPR), the latter quantifying the dissipation, at steady state. Applying this finding to a tRNA selection network in protein synthesis, we observe that the network tends to maximize both the EPR and catalytic rate, but not the accuracy. Simultaneously, the system tries to minimize the ratio of the EPRs due to the proofreading steps and the catalytic steps. Therefore, dissipation plays a guiding role in the optimization of the catalytic rate in the tRNA selection network of protein synthesis.
Cite this Research Publication : The guiding role of dissipation in kinetic proofreading networks: Implications for protein synthesis, K. Banerjee, B. Das, and G. Gangopadhyay, Journal of Chemical Physics (Communication),152, 111102, 2020.