Publications

Abstract :

Introduction: Treatment of early-onset mania proves to be challenging in the face ofchronicity and comorbidities, especially when the conventional anti-manic medications areineffective or poorly tolerated.Case history: A 14-year-old girl with moderate intellectual disability, presented withsymptoms suggestive of manic episode without psychotic symptoms. Poor tolerability of thefirst-line antimanic medications namely lithium, valproate, risperidone, quetiapine, andaripiprazole impeded the effective management of the episode. In this background, addition ofclonidine was followed by significant reduction in the severity of core manic symptoms.

Discussion: Clonidine has been found to be effective in hyperadrenergic states includingmania, particularly in a subset of refractory patients as well as those who have poor tolerabilityto lithium and antipsychotic drugs.