Publication

Abstract : Coumarins constitute an important class of flavonoids having enormous application in fields like chemosensing, optoelectronics, biomedicince, tissue engineering, etc. Coumarins have shown multi-functionalization properties, which enables them to participate in prominent energy/charge transfer processes, resulting in intriguing emission properties. Various coumarin-based fluorescent probes have found widespread application in detecting biologically relevant analytes with regulated fluorescence property. Such stimuli-dependent fluorescent property of coumarins makes them a handy class of compounds for medicinal application with real-time monitoring. Several coumarin derivatives have shown proficient photoactivity owing to their two-photon absorption abilities, affinities towards cycloaddition reaction, presence of photocleavable bonds, long-range near-infrared (NIR) absorption, etc. Photodynamic therapy (PDT) is one of the most promising cancer treatments due to its localized and non-invasive nature. Furthermore, the distinct heterogeneous environment of cancer cells compared to normal cells have often been used as an important stimulus to achieve target-specific therapy. In this article, we have tried to summarize some of the prominent examples of photoactivities of coumarin including stimuli-responsive fluorescent properties with a focus on redox-responsive PDT applications.