Publication Type : Journal Article
Publisher : American Chemical Society
Source : Organic Letters, 2012
Campus : Amritapuri
School : School of Biotechnology
Year : 2012
Abstract : Synergistic effects of the exo- and endocyclic chiral centers of an imidazolidinone-based auxiliary were investigated in the perspective of acetate aldol reactions. The reversal in diastereoselectivity was accomplished by lithium and titanium enolate reactions, which proceed through proposed open and closed transitions states, respectively. The aldol adducts were used in the stereoselective synthesis of fluoxetine.
Cite this Research Publication : Gopal L. Khatik, Varun Kumar and Vipin A. Nair, "Reversal of selectivity in acetate aldol reactions of N-acetyl-(S)-4-isopropyl-1-[(R)-1-phenylethyl] imidazolidin-2-one", Organic Letters, 2012, 14, 2442-2445