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Publication Type : Journal Article
Publisher : Elsevier
Source : Tetrahedron Letters, 2013
Campus : Amritapuri
School : School of Biotechnology
Verified : No
Year : 2013
Abstract : An imidazolidin-2-one chiral auxiliary mediated acetate aldol reaction was explored in the enantioselective synthesis of (S)-dapoxetine (SSRI). The diastereoselective aldol adduct was transformed to highly enantiopure (S)-dapoxetine with overall good yield.
Cite this Research Publication : Gopal L. Khatik, Ratnesh Sharma, Varun Kumar, Mangilal Chouhan and Vipin A. Nair, "Stereoselective synthesis of (S)-dapoxetine: a chiral auxiliary mediated approach", Tetrahedron Letters 2013, 54, 5991-5993