Publication Type : Journal Article
Publisher : Elsevier
Source : Tetrahedron Letters, 2016
Campus : Amritapuri
School : School of Biotechnology
Verified : No
Year : 2016
Abstract : Glycolate alkylation reactions of (S)-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one auxiliary has been optimised with high yields and diastereoselectivity on substituted benzyl and allyl bromides. The standardised reaction condition was employed for the stereoselective synthesis of EEHP and EMHP intermediates of PPAR agonists.
Cite this Research Publication : Mukesh Gangar, Harikrishnan M., Sandeep Goyal, Maulik N. Mungalpara and Vipin A. Nair, "A highly efficient and enantioselective synthesis of EEHP and EMHP: intermediates of PPAR agonists", Tetrahedron Letters 2016, 57, 3462-3467