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Course Detail

Course Name Omics in Translational Medicine
Course Code 24TM505
Program M.Sc. in Translational Medicine
Semester 1
Credits 3
Campus Faridabad

Syllabus

Unit 1:
Introduction to Omics Technologies; Overview of genomics, transcriptomics, proteomics, metabolomics, and other omics approaches, High-throughput sequencing technologies (NGS, RNA-seq, ChIP-seq, etc.), Genomics in Translational Medicine; Genome sequencing and variant analysis, Association studies and genome-wide association studies (GWAS), Pharmacogenomics and personalized medicine

Unit 2:
Transcriptomics and Gene Expression Analysis, Transcriptome profiling techniques (microarrays, RNA-seq), Differential gene expression analysis, Gene co-expression networks and pathway analysis.

Unit 3:
Mass spectrometry-based proteomics and metabolomics, Proteomics and Protein Biomarker Discovery; Mass spectrometry-based proteomics workflows, Identification and validation of protein biomarkers, Clinical applications of proteomics in disease diagnosis and monitoring

Unit 4:
Metabolomics and Metabolic Profiling; Metabolite identification and quantification, Metabolic pathway analysis, Metabolomics in drug metabolism and toxicology, Integrative Omics Approaches; Multi-omics data integration, Systems biology and network analysis, Translational applications of integrated omics approaches. Data Analysis and Bioinformatics Tools; Statistical analysis of omics data, Bioinformatics pipelines for data processing and interpretation, Visualization techniques for omics data analysis.

Unit 5:
Ethical, Legal, and Regulatory Considerations; Data privacy and confidentiality, Informed consent and patient rights, Regulatory pathways for omics-based diagnostics and therapeutics.

Objectives and Outcomes

Preamble

Omics in Translational Medicine is a graduate-level course designed to provide students with an advanced understanding of high-throughput omics technologies and their applications in translational medicine. The course will cover genomics, transcriptomics, proteomics, metabolomics, and other omics approaches, with a focus on their integration and utilization in biomedical research and clinical practice. Through lectures, case studies, and hands-on analysis of omics data, students will learn about omics-driven discovery, biomarker identification, personalized medicine, and other translational applications.

Course outcome

CO1: To understand the principles and methodologies of various omics technologies.
CO2: To explore the applications of genomics, transcriptomics, proteomics, and metabolomics in translational medicine.
CO3: To learn about data analysis techniques and bioinformatics tools for omics data interpretation.
CO4: To examine case studies and examples of omics-driven research in disease diagnosis, prognosis, and treatment.
CO5: To discuss ethical, legal, and regulatory considerations related to omics research and clinical implementation.
CO6: To develop practical skills in analyzing and interpreting omics data sets.

Program outcome (PO)

PO1: Utilize scientific principles and methodologies to design innovative solutions for data analysis, experimentation, and product development for challenges in translational research.
PO2: Recognize the importance of environmental sustainability in translational research and strive to minimize adverse environmental impacts.
PO3: Engage in ethical conduct, leadership, active listening, constructive feedback, and interpersonal communication to facilitate productive collaborations and knowledge exchange.
PO4: Acquire fundamental and advanced knowledge and skills in project management, financial planning, and entrepreneurship relevant to translational research ventures and initiatives.
3 = High Affinity, 2 = Medium Affinity, 1 = Low Affinity, – = No Affinity

PO1 PO2 PO3 PO4
CO 1 3 3 3
CO 2 3 3 3
CO 3 3 3 3
CO 4 3 3 3
CO 5 3 3 3
CO 6 3 3 3

Program Specific Outcome (PSO)

PSO1: Addresses the complexity of interdisciplinary sciences in biological and medical contexts.
PSO2: Deals with regulatory affairs in medicine, covering topics such as ethical considerations and regulatory frameworks.
PSO3: Covers compounds as drugs and their efficacy, involving pharmacology and drug development.
PSO4: Explores the intersection of bioinformatics and artificial intelligence in biology and medicine.
PSO5: Deals with technology in personalizing medicine, involving precision medicine approaches.
PSO6: Focuses on communicating and disseminating science and medicine to the public, involving science communication and public outreach efforts.

  PSO1 PSO2 PSO3 PSO4 PSO5 PSO6
CO 1 3 1 3 1
CO 2 3 1 3 1
CO 3 3 1 3 1
CO 4 3 1 3 1 2
CO 5 3 3 1 3 1 2
CO 6 3 1 3 1

Textbooks

Twyman, R., 2018. Advanced molecular biology: a concise reference. Garland Science.
Alberts, B., 2017. Molecular biology of the cell. (5th Edition) Garland science.

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