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Hypofractionated Radiotherapy for Stage I Squamous Cell Carcinoma Glottis: An Experience with 60Gy in 20 Fractions

Publication Type : Journal Article

Publisher : Iranian Journal of Medical Physics

Source : October 2023; Iranian Journal of Medical Physics Volume 20(Issue 4):226-232: DOI: 10.22038/IJMP.2022.62774.2073

Url : https://www.researchgate.net/profile/Pushpaja-Ullattil/publication/374754848_Hypofractionated_Radiotherapy_for_Stage_I_Squamous_Cell_Carcinoma_Glottis_An_Experience_with_60Gy_in_20_Fractions/links/652e0dc5b5c77c79f9bd9df1/Hypofractionated-Radiotherapy-for-Stage-I-Squamous-Cell-Carcinoma-Glottis-An-Experience-with-60Gy-in-20-Fractions.pdf

Campus : Kochi

School : School of Medicine

Year : 2023

Abstract :

Introduction:

Early-stage glottic cancer has a high cure rate with definitive radiotherapy. Historical reports show excellent local control. The present study evaluated the outcomes of early glottic cancer patients treated with a hypofractionated radiotherapy schedule of 60Gy in 20 fractions.

Material and Methods:

This is a retrospective study of patients with stage I glottic cancer who received radical intent LINAC-based hypo-fractionated 3D conformal radiotherapy with a dose 60Gy in 20 fractions. The primary objective was to assess the locoregional control (LRC), and secondary objectives were to determine disease-free survival (DFS), overall survival (OS), and toxicity.

Results:

The analysis included 105 patients from the age range of 35-88 years. About 69% of patients were over 60 years of age. The median overall treatment time (OTT) was 26 days (24 – 30 days). The mean follow-up was 74 months, ranging from 9 to 135 months. Seven patients had locoregional recurrence after an initial complete clinical response. Six had local, and one had a regional nodal recurrence. DFS at five years and ten years were 83% and 69%, and OS at five years and ten years were 87% and 80%, respectively. Most patients reported grade I skin reactions and tolerated the treatment well. We did not observe any late adverse events such as persistent laryngeal edema or radiation necrosis.

Conclusion:

The radiotherapy schedule of 60Gy in 20 fractions over four weeks offers comparable local disease control with reasonable long-term side effects in T1 glottic cancer.

Cite this Research Publication : Pushpaja KU, Nair AR, Mazhoor SN, Lakshmi JS, Dutta D. "Hypofractionated Radiotherapy for Stage I Squamous Cell Carcinoma Glottis: An Experience with 60Gy in 20 Fraction," October 2023; Iranian Journal of Medical Physics Volume 20(Issue 4):226-232: DOI: 10.22038/IJMP.2022.62774.2073

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