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Dr. Martin Reick

Visiting Faculty, School of Biotechnology, Amritapuri

Qualification: Ph.D
martin@am.amrita.edu

Bio Publications
Bio

Research Interests

In India, envenomation by members of the four major venomous snakes species, spectacled cobra (Naja naja), common krait (Bungarus caeruleus) saw scaled viper (Echis carinatus) and Russell’s viper (Daboia russelii,) leads to about 12,000 death per year that are clinically recorded and an estimated number of 46,000 death per year over all. A large proportion of the bites and deaths are thought to go unrecorded because they occur in rural areas among poorer segments of the population where timely and effective antivenom treatments are either not available or too expensive.

Antibody based antivenom preparations have two major sources of variability, variability of the venom source used for immunization and variability in the immune response of the animal to be immunized. Furthermore, antibody based antivenom may also elicit serious immune reactions and complications in the recipient since they are usually derived from a heterologous species.

With this in mind, we decided to develop alternative approaches to antivenom production in which individual venom components are first isolated and then individually targeted for inhibition using either random peptide libraries or potential small molecules available. Once good inhibitors have been developed for the relevant toxin componenets, these can then be combined and tested for their ability to neutralize the venom in in vivo models.

 

Publications

Journal Article

Year : 2003

Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice

Cite this Research Publication : C. A. Dudley, Erbel-Sieler, C., Estill, S. Jo, Dr. Martin Reick, Franken, P., Pitts, S. N., and McKnight, S. L., “Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice”, Science, vol. 301, pp. 379–383, 2003.

Publisher : American Association for the Advancement of Science

Year : 2002

Metabolism and the control of circadian rhythms

Cite this Research Publication : J. Rutter, Dr. Martin Reick, and McKnight, S. L., “Metabolism and the control of circadian rhythms”, Annual review of biochemistry, vol. 71, pp. 307–331, 2002.

Publisher : Annual review of biochemistry , Annual Reviews 4139 El Camino Way, PO Box 10139, Palo Alto,

Year : 2002

Characterization of U2AF6, a splicing factor related to U2AF35

Cite this Research Publication : J. Shepard, Dr. Martin Reick, Olson, S., and Graveley, B. R., “Characterization of U2AF6, a splicing factor related to U2AF35”, Molecular and cellular biology, vol. 22, pp. 221–230, 2002.

Publisher : Molecular and cellular biology, Am Soc Microbiol

Year : 2001

Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors

Cite this Research Publication : J. Rutter, Dr. Martin Reick, Wu, L. C., and McKnight, S. L., “Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors”, Science, vol. 293, pp. 510–514, 2001.

Publisher : American Association for the Advancement of Science

Year : 2001

NPAS2: an analog of clock operative in the mammalian forebrain

Cite this Research Publication : Dr. Martin Reick, Garcia, J. A., Dudley, C., and McKnight, S. L., “NPAS2: an analog of clock operative in the mammalian forebrain”, Science, vol. 293, pp. 506–509, 2001.

Publisher : American Association for the Advancement of Science

Year : 2000

Impaired cued and contextual memory in NPAS2-deficient mice

Cite this Research Publication : J. A. Garcia, Zhang, D., Estill, S. Jo, Michnoff, C., Rutter, J., Dr. Martin Reick, Scott, K., Diaz-Arrastia, R., and McKnight, S. L., “Impaired cued and contextual memory in NPAS2-deficient mice”, Science, vol. 288, pp. 2226–2230, 2000.

Publisher : Science American Association for the Advancement of Science

Year : 1994

Down-regulation of nuclear aryl hydrocarbon receptor DNA-binding and transactivation functions: requirement for a labile or inducible factor.

Cite this Research Publication : Dr. Martin Reick, Robertson, R. W., Pasco, D. S., and Fagan, J. B., “Down-regulation of nuclear aryl hydrocarbon receptor DNA-binding and transactivation functions: requirement for a labile or inducible factor.”, Molecular and cellular biology, vol. 14, pp. 5653–5660, 1994.

Publisher : Am Soc Microbiol

Conference Proceedings

Year : 2017

Proteomic investigation of Trimeresurus malabaricus venom and its comparative functional analysis using Daboia Russelii venom, SnakeSymp-Snake venom research and snakebite therapy

Cite this Research Publication : Muralidharan Vanuopadath, Aswathy Alangode, Karthika Rajan, Nithin Sajeev, Dileepkumar Raveendran, Martein Reick, Margaret Reick, Bipin Gopalakrishnan Nair, Sudarslal Sadasivan Nair, Proteomic investigation of Trimeresurus malabaricus venom and its comparative functional analysis using Daboia Russelii venom, SnakeSymp-Snake venom research and snakebite therapy, Centre for Cellular and Molecular Biology, Hyderabad, India, December 1-3, 2017.

Year : 2013

Natural Product Mediated Modulation of a Russell’s Viper Metalloprotease Fibrinogenolytic Activity

Cite this Research Publication : A. Alangode, Reick, M., Dr. Martin Reick, and Nair., B., “Natural Product Mediated Modulation of a Russell's Viper Metalloprotease Fibrinogenolytic Activity”, Elsevier Publications. 2013.

Publisher : Elsevier Publications

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