Publication

Abstract : The plant mediated biogenic synthesis of nanoparticles is of magnificent concern due to its eco-benignand single pot nature. Here, Cinnamomum tamala (C. tamala) aqueous leaf extract was utilised for the silvernanoparticles’ (Ag NPs) synthesis. The phytoconstituents in the leaf extract were analysed by standard methods.These metabolites, especially carbohydrate polymers reduce Ag ions to Ag NPs accompanied by a reddish-browncoloration of the reaction mixture. The visual observation of intense brown colour is the first indication of theformation of Ag NPs. Various spectro-analytical techniques further characterise the Ag NPs. The greensynthesised spherical Ag NPs were crystalline with an average size of 38 nm. The Ag NPs were scrutinised forantioxidant, antimicrobial and cytotoxic activity and obtained good results. The free radical scavenging wasstudied by 2, 2-Diphenyl-l-picrylhydrazyl (DPPH) assay. The antibacterial activity of Ag NPs was assessedagainst human pathogens, and it shown to have good antibacterial potency against a wide spectrum of bacteria.The cytotoxic activity against HEK-293T (human embryonic kidney) cell line was evaluated by2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assay. These potent biologicalactivities enable C. tamala capped Ag NPs to be suitable candidates for the future applications in various fields,predominantly clinical and biomedical.