Publication Type : Journal Article
Publisher : IJCB
Source : International. Journal for Computational Biology (IJCB) 2019, 8 (1).
Campus : Amritapuri
School : School of Biotechnology
Department : Chemistry
Year : 2019
Abstract : Type 2 diabetes mellitus (T2DM) is a leading endocrine disorder that affects millions of people worldwide. It is characterized by hyperglycemia and high insulin resistance. The commonly prescribed oral therapeutic for insulin resistance in T2DM is Thiazolidine-2, 4-diones (TZDs). TZDs are a class of oral hypoglycemic agents that act on Peroxisome proliferator activating receptor-γ (PPAR-γ) receptors and are mainly expressed in the adipose tissues. In this work, we derive novel classes of TZDs and predict the nature of Keyword: structural affinity using docking studies against the PPAR-γ
Cite this Research Publication : Tiwari, P.; Suravajhala, R.; Gupta, S.; Chaturvedi, P.; Mathur, S. K.; Solanki, P. S.; Malik,B. A Molecular Docking and Pharmacokinetic Prediction of Thiazolidine-2, 4-Dione Derivatives: Toward Novel Therapeutic Targets for Type-2 Diabetes Mellitus. International. Journal for Computational Biology (IJCB) 2019, 8 (1).