Publication

Abstract : The implication of a successful mathematical model in applied genomics requires mathematical modeling of regulatory cascades in a gene-regulated network in autoimmune disorders (AIDs) such as psoriasis, is a difficult job to complete in the current age of applied genomics. There were four computational approaches used to address the challenge:(a) Gene Assisted Cascade Regulation,(b) Differential Gene Expression Cascade,(c) Gene Variant Cascade, and (d) Biologic Cascade to identify a potential biomarker for treating AIDS in the future, and finally, the reconstructed network concerning activation and deactivation loops that were subjected to mathematical modeling to understand and identify the mechanism of regulatory cascade in pathogenesis.