Publication

Abstract : Psoriasis Vulgaris is a complex auto immune disorder which results in poorly differentiated hyper proliferative keratinocytes. Psoriasis had been widely studied in the past for a decade using HLA gene and the addition factors which are required for the activation and deactivation of the gene present in the skin lesions of patients suffering with Psoriasis. In this review, we analyze the prevalence and pathology and of Psoriasis across the globe with the recent advancement from candidate gene study HLA genes to Genome Wide Association Study (GWAS) along with the impact of nanotechnology towards the drug delivery of small RNAs of non coding families (ncRNAs) like small interfering RNA (siRNA), miRNA and etc with the help of a carrier molecule to activate and bind to the receptor. In addition to that there were well established studies of miRNA to illustrate its vital role in characterizing the disease pathology of Psoriasis and provide an alternative path towards the treat Psoriasis in future.