Publication

Abstract : Introduction: Bladder cancer is the most expensive and time consuming malignancy because of it high recurrence rate and disease progression. FGFR3 mutation in bladder cancer is associated with non muscle invasive and low grade disease this making it a non invasive marker of for nonaggressive disease. AIM: e aim of this study was to detect FGFR3 mutation in a single voided urine sample of bladder cancer patients in Indian population and its diagnostic and prognostic performance. MATERIALS AND METHOD:A prospective observational study was carried out with one-year follow-up of primary bladder tumor patients . Urine samples were collected before TURP. Screening for the most prevalent FGFR3 mutations was done using urinary cells. e prognostic significance of an FGFR3 mutation at the time of the initial diagnosis was determined. e performance of the test in diagnosing and/or predicting recurrence during follow up was assessed . RESULTS: Of 39 patients studied, 2 (5.62%) had a positive analysis before TUR (FGFR3 MT). ere was no statistical significance between MT and WT when compared with grade and stage of tumor. Neither there was any significant risk of tumor recurrence and progression in FGFR3 mutated as compared to wild type group. Conclusion: Among patients with an FGFR3 mutation in the initial tumor, a noninvasive urine test from a single voided sample before primary resection cannot be valuable in diagnosing or predicting subsequent recurrence or progression.