Publication Type : Journal Article
Thematic Areas : Medical Sciences, Nanosciences and Molecular Medicine
Publisher : Nanomedicine
Source : Nanomedicine, Volume 16, Issue 12, p.997-1015 (2021)
Url : https://pubmed.ncbi.nlm.nih.gov/33970682/
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move
Department : Nanosciences and Molecular Medicine
Year : 2021
Abstract : To develop a method for making total serum nanoparticles (TSN) loaded with cytotoxic chemodrugs for cancer therapy. TSN loaded with paclitaxel (PTX) or piperlongumine (PL) were prepared using high-pressure homogenization and tested for immunogenicity in healthy animals and antitumor properties in pancreatic cancer xenograft models. TSN-PL nanoparticles of average size 104 nm and encapsulation efficiency approximately 50% showed enhanced dose-dependent cytotoxicity compared with TSN-PTX or clinically used combination of gemcitabine and nano-PTX in two pancreatic cell lines. Significant antitumor efficacy was also established in the pancreatic xenograft model. We developed a unique method of converting total blood serum into chemo drug-loaded nanoparticles and demonstrated its efficacy
Cite this Research Publication : Jyotsna Thayath, Dr. Pavithran K., Shantikumar V Nair, and Dr. Manzoor K., “Cancer nanomedicine developed from total human serum: a novel approach for making personalized nanomedicine.”, Nanomedicine, vol. 16, no. 12, pp. 997-1015, 2021.