Publication

Abstract : Aspartate pathway is essential in bacteria, fungi and plants. Any block in the pathway is lethal to the organism. Microbial resistance towards the drug molecule and the side effects exhibited by the drugs are the key basis for searching novel antimicrobial compounds. Since ancient times, medicinal plants are serving as remedies for several diseases and as a source for variety of components. The present study aims on identifying the potential phytocompounds reported from Sphaeranthus indicus and Wrightia tinctoria that can inhibit the pathway enzymes viz., Aspartate kinase, Aspartate semialdehyde dehydrogenase, Homoserine dehydrogenase and Homoserine O-Acetyl transferase. The availability of literature for this pathway is very limited and this work would serve as basis for exploring unique antifungal targets in the future. Among the phytocompounds docked, the first five compounds showing least G. score value were considered. Docking studies conclude rutin, sphaeranthanoloide and chlorogenic acid as potent inhibitors that can be further studied for developing antifungal agents.