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Publication Type : Journal Article
Thematic Areas : Medical Sciences
Source : VOLUME 21, ISSUE 8, E246-E257, AUGUST 01, 2021
Url : https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30784-2/fulltext
Campus : Kochi
School : School of Medicine
Department : Microbiology
Year : 2021
Abstract : With increasing numbers of patients needing intensive care or who are immunosuppressed, infections caused by moulds other than Aspergillus spp or Mucorales are increasing. Although antifungal prophylaxis has shown effectiveness in preventing many invasive fungal infections, selective pressure has caused an increase of breakthrough infections caused by Fusarium, Lomentospora, and Scedosporium species, as well as by dematiaceous moulds, Rasamsonia, Schizophyllum, Scopulariopsis, Paecilomyces, Penicillium, Talaromyces and Purpureocillium species. Guidance on the complex multidisciplinary management of infections caused by these pathogens has the potential to improve prognosis. Management routes depend on the availability of diagnostic and therapeutic options. The present recommendations are part of the One World—One Guideline initiative to incorporate regional differences in the epidemiology and management of rare mould infections. Experts from 24 countries contributed their knowledge and analysed published evidence on the diagnosis and treatment of rare mould infections. This consensus document intends to provide practical guidance in clinical decision making by engaging physicians and scientists involved in various aspects of clinical management. Moreover, we identify areas of uncertainty and constraints in optimising this management.
Cite this Research Publication : Martin Hoenigl, Jon Salmanton-García, Prof Thomas J Walsh, Marcio Nucci, Chin Fen Neoh, Jeffrey D Jenks, Michaela Lackner, Rosanne Sprute, Abdullah M S Al-Hatmi, Prof Matteo Bassetti, Fabianne Carlesse, Tomas Freiberger, Philipp Koehler, Thomas Lehrnbecher, Prof Anil Kumar, Juergen Prattes, Prof Malcolm Richardson, SanjayRevankar, Prof Monica A Slavin, Jannik Stemler, Birgit Spiess, Saad J Taj-Aldeen, PhD Adilia Warris, MD Patrick C Y Woo, MD Prof Jo-Anne H Young, MD Kerstin Albus, MSc Dorothee Arenz, PhD Valentina Arsic-Arsenijevic, MD Jean-Philippe Bouchara, PhD Terrence Rohan Chinniah, MD Anuradha Chowdhary, MD G Sybren de Hoog, PhD George Dimopoulos, MD Rafael F Duarte, MD Petr Hamal, MD Prof Jacques F Meis, MD Sayoki Mfinanga, MD Flavio Queiroz-Telles, MD Prof Thomas F Patterson, MD Galia Rahav, Thomas R Rogers, Coleman Rotstein, Retno Wahyuningsih, Danila Seidel, Prof Oliver A Cornely "Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology", Lancet Infect Dis, 2021.