Publication

Abstract : Background: During the development of Multiple Sclerosis (MS) there is a marked activation of microglia and astrocyte, leading to progressive inflammation and degeneration of myelin sheath which results in axonal loss and neuron damage.

Purpose: In this study, we have explored the action of Asiaticoside A against the activated microglia and astrocytes.

Methods: Primary microglia and astrocyte cultures were used for the study and the activity were evaluated using cell proliferation assay, nitrate assay and TNFα estimation using ELISA.

Results: Asiaticoside A inhibited the production of nitric oxide and TNFα in LPS activated primary microglia and astrocyte cultures.

Conclusion: This study suggests that Asiaticoside A may be effective against the progression of MS.