Publication Type : Journal Article
Source : (2016)
Url : http://www.eurekaselect.com/node/140921/article
Keywords : cheese effect, depression, docking., MAO-A, MAO-B, Parkinson’s disease
Campus : Kochi
School : School of Pharmacy
Center : Research & Projects
Department : Pharmaceutical Chemistry & Analysis
Year : 2016
Abstract : Monoamine oxidase-A and B have been studied over a long period as one of the promisingdrug targets for the treatment of depression and neurodegenerative disorders. Commonly, MAO-A is associated with depressionbecause of its relation with the control of serotonin levels. On the other hand, MAO-B has been associated with Alzheimer’sand Parkinson’s diseases because this enzyme modulates dopamine levels in the CNS. The major objective of theresearch in this field is devoted to identify and isolate selective ligands of MAO-A/MAO-B so that the undesirable side effectsdue to non-selective inhibition of monoamine catabolism by the isoforms can be avoided. This review will give an overviewof the inhibition mechanism of MOA and its biochemistry, along with the history and development of MAO inhibitorsincluding the significance of molecular modeling studies for the identification of novel class of MAO inhibitors.
Cite this Research Publication : Bijo Mathew, Mathew, G. E., Suresh, J., Ucar, G., Sasidharan, R., Anbazhagan, S., and Jayaprakash, J. K. Vilapur, “Monoamine Oxidase Inhibitors: Perspective Design for the Treatment of Depression and Neurological Disorders”, 2016.