Publication

Abstract : Combinatorial synthesis revolutionized the drug industries in this century. After a sequence of procedures parallel generation of molecules carried out and follows high throughput screening assays. Genomic and proteomic studies lead us to design promising molecule that bind in diseased targets. Success in lead discovery requires computational methods, data mining tools and docking procedures. Automated computational technologies reduced time and wastage of money in synthesizing new molecules while whole world is suffering from worst diseases. Building of novel drug is a complex process. In olden days active compounds used in drug discovery programs have been natural products, isolated from plant, animal or fermentation sources. Combinatorial chemistry is one of the important technique developed by researchers in the pharmaceutical industry to minimize the time and costs associated with producing effective and competitive new drugs. By combinatorial chemistry large number of analogues is generated using the same reaction conditions, the same reaction vessels. Traditional synthesis of drug was tedious process which involves one compound at a time