Publication Type : Conference Paper
Thematic Areas : Advanced Materials and Green Technologies
Publisher : Materials Today: Proceedings
Source : Materials Today: Proceedings, Elsevier Ltd, Volume 5, Number 8, p.16580-16584 (2018)
Campus : Coimbatore
School : School of Engineering
Center : Center for Excellence in Advanced Materials and Green Technologies
Department : Chemical, Civil
Year : 2018
Abstract : pGlycine based peptide nucleic acid (PNA) monomers are useful in the construction of PNA oligomers which are, in general, hydrophobic in nature. To overcome this huddle, serine based peptide nucleic acid (PNA) monomer was synthesized which will a good candidate in terms of increasing hydrophilicity. The synthesis involves in the alkylation of N-bromoethyl phthalimide on nosyl protected serine methyl ester followed by deprotection and condensation with nucleobase yields PNA monomer. The phthalimide group on nitrogen serves as protecting group as well as marker. © 2017 Elsevier Ltd./p
Cite this Research Publication : S. Sivakumar, Ramani, P., and Shilpa, G. S., “Phthalimido protected peptide nucleic acid monomer - Synthesis and Characterization”, in Materials Today: Proceedings, 2018, vol. 5, pp. 16580-16584.