Publication Type : Journal Article
Thematic Areas : Advanced Materials and Green Technologies
Publisher : RSC Advances
Source : RSC Advances, (2016) Vol. 6, 62385-62389.
Campus : Coimbatore
School : School of Biotechnology, School of Engineering
Center : Amrita Innovation & Research, Center for Excellence in Advanced Materials and Green Technologies
Department : biotechnology, Chemical, Civil
Verified : Yes
Year : 2016
Abstract : A water-soluble and biocompatible polymer i. e. biotinylated poly(vinyl alcohol) grafted graphene oxide (GO) was used as a nanocarrier for targeted delivery of anticancer drug camptothecin (CPT). The extent of CPT release in the presence of glutathione (GSH) from GO-biotinPVA-CPT was monitored by the increase in the fluorescence intensity at λmax 450 nm. The cell specific (HeLa) antiproliferative activity of GO-biotinPVA-CPT makes it suitable to be used in targeted delivery of chemotherapeutics to cancerous cells.
Cite this Research Publication : Y. Yasoda, Bobba, K., Nedungadi, D., Dutta, D., Kumar, S., Kothurkar, N., Mishra, N., and Bhuniya, S., “GSH Responsive Biotinylated Poly(vinyl alcohol) Grafted GO as a Nanocarrier for Targeted Delivery of Camptothecin†”, RSC Adv., vol. 6, 2016.