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Free radical scavenging and antibacterial activity of Mirabilis jalapa Linn using in vitro models

Publication Type : Journal Article

Publisher : Asian Journal of Pharmaceutical and Clinical Research

Source : Asian Journal of Pharmaceutical and Clinical Research, vol. 5, pp. 115-120, 2012

Url : http://www.scopus.com/inward/record.url?eid=2-s2.0-84875413821&partnerID=40&md5=46579f0809335d862df4c7dfd6f97a5c

Keywords : alkaloid, antibacterial activity, antiinfective agent, antioxidant, antioxidant activity, article, ascorbic acid, Bacillus, chemical analysis, chloramphenicol, controlled study, flavonoid, in vitro study, methanol, minimum inhibitory concentration, Mirabilis, mirabilis jalapa, mirabilis jalapa extract, nonhuman, phenol derivative, plant extract, polyphenol derivative, Pseudomonas, Staphylococcus aureus, tannin derivative, unclassified drug

Campus : Kochi

School : School of Pharmacy

Department : Pharmaceutics

Year : 2012

Abstract : Medicinal plants form a major source of raw materials for drugs for the prevention and treatment of ailments. Mirabilis jalapa linn is used as antinociceptive, anti-inflammatory agent, laxative in folk medicine. Antioxidants play an important role in protecting against damage by reactive oxygen species.The present study was designed to evaluate the plant potential as an antioxidant lead by using various in vitro models like Hydrogen peroxide scavenging method and reducing power assay method and also to determine its antibacterial potential. Preliminary phytochemical screening revealed the presence of alkaloids, flavonoids, polyphenols like phenolic compounds and tannins. The total flavanoid content of the extract was found to be 4.41 ± 0.02 mg /gram. The plant exhibited significant antioxidant properties and could serve as a free radical inhibitor or scavenger. The antibacterial activity of the extracts was determined by the agar well diffusion method. The greatest zone of inhibition was displayed by methanolic extract against pseudomonas at 3mg/ml. With a wide spectrum of inhibition against Gram-positive and Gram-negative bacteria, the methanolic extract of Mirabilis jalapa are worthy of further investigation as a natural wide spectrum antibacterial agent. These results indicates the potential of Mirabilis jalapa as a source of antioxidant and antibacterial compound.

Cite this Research Publication : Dr. Subin Mary Zachariah, Dr. Vidya Viswanad, Aleykutty, N. Ab, Jaykar, Bc, and Halima, O. Aa, “Free radical scavenging and antibacterial activity of Mirabilis jalapa Linn using in vitro models”, Asian Journal of Pharmaceutical and Clinical Research, vol. 5, pp. 115-120, 2012

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