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Ferrocene derivatives supported on poly(N-vinylpyrrolidin-2-one) (PVP): Synthesis of new water-soluble electrochemically active probes for biomolecules

Publication Type : Journal Article

Publisher : Journal of Organometallic Chemistry

Source : Journal of Organometallic Chemistry, Volume 692, Number 6, p.1363 - 1371 (2007)

Url : http://www.sciencedirect.com/science/article/pii/S0022328X06008989

Keywords : Polymer conjugation

Campus : Coimbatore

School : School of Engineering

Department : Sciences

Year : 2007

Abstract : pCarboxy-terminated polyvinylpyrrolidin-2-one (PVP) has been used as a new water-soluble and biocompatible polymeric support for a series of ferrocene labeled amino acid and peptide nucleic acid (PNA) monomer derivatives 4–7. The organometallic polymer-conjugates thus obtained are new and potentially useful as water-soluble electrochemically active probes for biomolecules. In view of such application, their electrochemical activity has been evaluated and has proved very high notwithstanding the complexity and bulkiness of the molecule, affording detection limits down to 10−8nbsp;M in the aqueous medium./p

Cite this Research Publication : C. Baldoli, Oldani, C., Licandro, E., Dr. Prasanna Ramani, Valerio, A., Ferruti, P., Falciola, L., and Mussini, P., “Ferrocene derivatives supported on poly(N-vinylpyrrolidin-2-one) (PVP): Synthesis of new water-soluble electrochemically active probes for biomolecules”, Journal of Organometallic Chemistry, vol. 692, pp. 1363 - 1371, 2007.

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