Publication Type : Journal Article
Thematic Areas : Medical Sciences
Publisher : Journal of Ethnopharmacology
Source : Journal of Ethnopharmacology, Volume 29, Number 1, p.35-41 (1990)
Keywords : animal, animal cell, animal experiment, animal model, Antineoplastic Agents, article, cancer graft, Cell culture, Cell Line, cell strain KB, Cell Survival, CHO cell, Cultured, cytotoxicity, Ehrlich ascites tumor cell, Experimental, human, human cell, intramuscular drug administration, intraperitoneal drug administration, lymphocyte, Lymphocytes, lymphoma cell, Medicinal, Mice, Mistletoe, mouse, Neoplasms, nonhuman, Phytogenic, phytohemagglutinin, Plant Extracts, Plants, priority journal, spleen cell, Tumor Cells, Tumor growth, Viscum album
Campus : Kochi
School : School of Medicine
Year : 1990
Abstract : The effect of Iscador, a commercial preparation made from Viscum album was studied on several cell lines using in vitro tissue culture as well as tumor-bearing animals. Iscador was found to be cytotoxic to animal tumor cells such as Dalton's lymphoma ascites cells (DLA cells) and Ehrlich ascites cells in vitro and inhibited the growth of lung fibroblasts (LB cells), Chinese hamster ovary cells (CHO cells) and human nasopharyngeal carcinoma cells (KB cells) at very low concentrations. Moreover, administration of Iscador was found to reduce ascites tumours and solid tumours produced by DLA cells and Ehrlich ascites cells. The effect of the drug could be seen when the drug was given either simultaneously, after tumour development or when given prophylactically, indicating a mechanism of action very different from other chemotherapeutic drugs. Iscador was not found to be cytotoxic to lymphocytes. © 1990.
Cite this Research Publication : R. Kuttan, Kuttan, G., and Dr. Damodaran Vasudevan, “Effect of a preparation from Viscum album on tumor development in vitro and in mice”, Journal of Ethnopharmacology, vol. 29, pp. 35-41, 1990.