Publication Type : Journal Article
Publisher : SpectrochimicaActa Part A
Source : SpectrochimicaActa Part A, 2011, 81, 276–282
Url : https://www.sciencedirect.com/science/article/abs/pii/S1386142511004999
Campus : Mysuru
Department : Chemistry
Year : 2011
Abstract : Four Schiff base ligands and their corresponding organotin(IV) complexes have been synthesized and characterized by elemental analyses, IR, 1H NMR, MS and thermal studies. The Schiff bases are obtained by the condensation of 3-amino-2-methyl-4(3H)-quinazolinone with different substituted aldehydes. The elemental analysis data suggest the stoichiometry to be 1:1 ratio formation. Infrared spectral data agreed with the coordination to the central metal ion through imine nitrogen, lactam oxygen and deprotonated phenolic oxygen atoms. All the synthesized compounds have been evaluated for antimicrobial activity against selected species of microorganisms. In addition, DNA binding/cleavage capacity of the compounds was analyzed by absorption spectroscopy, viscosity measurements and gel electrophoresis methods.
Cite this Research Publication : K. Shiva Prasad*et al.,“Diorganotin(IV) complexes of biologically potent 4(3H)-quinazolinone derived Schiff bases: Synthesis, spectroscopic characterization, DNA interaction studies and antimicrobial activity”SpectrochimicaActa Part A, 2011, 81, 276–282. DOI:10.1016/j.saa.2011.06.010