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Design and in vitro characterization of metformin loaded resealed erythrocytes

Publication Type : Journal Article

Publisher : Asian Journal of Pharmaceutical and Clinical Research, Innovare Academics Sciences

Source : Asian Journal of Pharmaceutical and Clinical Research, Innovare Academics Sciences Pvt. Ltd, vol. 10, pp. 231-238, 2017

Url : https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017159569&doi=10.22159%2fajpcr.2017.v10i4.16636&partnerID=40&md5=3abc7d98501cfa65139ae0cb83bc8c50

Campus : Kochi

School : School of Pharmacy

Department : Pharmaceutical Chemistry & Analysis

Year : 2017

Abstract : Objective: Metformin is an oral antidiabetic drug in the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes. The objective of this study was to retard the release of metformin using carrier erythrocyte for getting a parenteral slow release depot formulation. Methods: The study retards the release of metformin by encapsulating in carrier erythrocyte. Endocytosis is the method used for the encapsulation of the drug metformin. Results: The optimized formulation shows 98.34% of drug release within 12 days. From the in vitro release data, zero order kinetic graph shows the best fit graph. % cell recovered was found to be 73-78% and it suggests that the loading technique was less destructive. Conclusion: The optimized formulation is a perfect carrier for the parenteral slow release depot of metformin. © 2017 The Authors.

Cite this Research Publication : S. Aiswarya, Parvathy, S., Dr. Aneesh T. P., and Dr. Vidya Viswanad, “Design and in vitro characterization of metformin loaded resealed erythrocytes”, Asian Journal of Pharmaceutical and Clinical Research, vol. 10, pp. 231-238, 2017

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