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Creatine Kinase and Cardiotoxicity in Adriamycin Chemotherapy and its Modification by WR-1065

Publication Type : Journal Article

Thematic Areas : Medical Sciences

Publisher : Biochemical Archieves

Source : Biochemical Archieves, Volume 8, p.335-338 (1992)

Url : https://www.researchgate.net/publication/216208778_Creatine_Kinase_and_Cardiotoxicity_in_Adriamycin_Chemotherapy_and_its_Modification_by_WR-1065

Campus : Kochi

School : School of Medicine

Year : 1992

Abstract : The effect of adriamycin(ADR) chemotherapy on cratinine phosphokinase (CPK) and pathological lesions in heart was studied with Balb/c mice. WR-1065 was used as a chemoprotector against the cardiotoxicity of ADR. CPK levels were measured at different intervals and the heart of treated animals were analyzed for pathological changes. The results indicate that there is a significant relationship between the CPK levels and pathological lesions. WR-1065 could reduce tge cardiotoxicity induced by ADR, without altering its antineoplastic activity

Cite this Research Publication : Dr. Damodaran Vasudevan, “Creatine Kinase and Cardiotoxicity in Adriamycin Chemotherapy and its Modification by WR-1065”, Biochemical Archieves, vol. 8, pp. 335-338, 1992.


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