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Dr. Subin Mary Zachariah

Associate Professor, Pharmaceutical Chemistry & Analysis, School of Pharmacy, Kochi

Qualification: M. Pharm., Ph.D
subinmaryzachariah@aims.amrita.edu
Research Interest: Medicinal Chemistry & Drug Design, Phytochemistry

Bio

Dr. Subin Mary Zachariah, joined as Senior Lecturer in Amrita School of Pharmacy in September 2006. Currently she serves as Associate Professor in the Department of Pharmaceutical Chemistry and Analysis. She received her Ph. D. in Pharmaceutical Sciences from Vinayaka Missions University, Salem in January 2014. She has her B.Pharm from Swamy Vivekananda College of Pharmacy, Erode and later obtained her M.Pharm in Pharmaceutical Chemistry from K.M.College of Pharmacy, Madurai.

After obtaining her post graduation, she started her career in teaching in the year 2003. She worked one year in Bangalore as lecturer in Milind Institute of Pharmacy Bangalore and continued teaching in St. Joseph’s college of Pharmacy Cherthala till 2006.Then she joined Amrita School of Pharmacy from 2006 September onwards.

Dr. Subin Mary Zachariah’s areas of interest broadly include phytochemistry isolation, characterisation and pharmacological studies of biologically active compounds from medicinal plants, optimization of synthetic methodology leading to development of small molecules as diverse therapeutic agents. Currently, she is involved with 4H-chromene derivatives as a privileged scaffold for various in vitro and in vivo screening methods. A series of synthetic chromenes have been synthesized by her students followed by antioxidant, anti-inflammatory, antitubercular and anticancer compounds. Now, she is also actively involved in design and synthesis of new biologically active azetidinones.

She is actively involved in guiding B.Pharm and M.Pharm projects. Some of her recent projects are as follows.

  • Synthesis and Formulation of Novel 4-phenyl -4H chromene derivatives as Anticancer and antiinflammatory agents.
  • Design,synthesis,characterization and in vitro evaluation of some novel 3,4-dihydropyrimidine-2(1H)-one derivatives for the treatment of Breast carcinoma.
  • Synthesis and formulation of Novel 4-phenyl-4H-chromene derivatives as anti-inflammatory agents.
  • Design ,synthesis ,characterisation and pharmacological evaluation of some novel substituted 3,4-dihydropyrimidine-2(1H)-one derivatives.
  • In silico design,synthesis,characterization and in vitro antiinflammatory and antioxidant studies of 4aryl-4H chromene derivatives.
  • Isolation, characterisation and in vitro pharmacological activities of Tagetes erecta
  • Phytochemical screening, isolation and pharmacological activities of Caesalpinia pulcherrima
  • Phytochemical screening, antibacterial activity and formulation development of aqueous extract of dried galls of Quercus infectoria
  • Phytochemical standardisation and antioxidant evaluation of the roots of Mirabilis jalapa Linn
  • Evaluation of in vitro antioxidant, antimicrobial and cytotoxicity studies of methanolic extracts of Mirabilis jalapa Linn
  • Phytochemical screening  antioxidant and antimicrobial activity of aerial parts of  methanolic extracts of Mirabilis jalapa Linn
  • Insilico design, synthesis and in vitro studies of some novel 4-phenyl-4H-chromene derivatives as anticancer and antiinflammatory agents.
  • In silico design, synthesis and in vitro studies of some novel 4-phenyl-4H -Chromene derivatives as antioxidant and antiinflammatory agents.
Publications

Journal Article

Year : 2021

Detailed View on Repurposed Drugs, Tracking of Vaccines, and Brief View on Prophylactic Nanomedicines as an Alternative Approach and Patient Care for Covid-19

Cite this Research Publication : K. R. I. S. H. N. A. N. J. A. N. A. S. NAIR, KAMATH, S. H. I. V. A. L. I., RAJAN, A. R. Y. A., THOMAS, S. A. C. H. I. N., D., A. S. W. I. N., and Zachariah, S. Mary, “Detailed View on Repurposed Drugs, Tracking of Vaccines,and Brief View on Prophylactic Nanomedicines as an Alternative Approach and Patient Care for Covid-19”, International Journal of Applied Pharmaceutics, vol. 13, pp. 19-26, 2021.

Publisher : International Journal of Applied Pharmaceutics

Year : 2020

Design, Synthesis, Characterization And In Vitro Evaluation Of Some Novel 3, 4-Dihydropyrimidine-2(1h)-One Derivatives For The Treatment Of Breast Carcinoma

Cite this Research Publication : N. George, M., A. Asokan, Ajish,, Pappachen, L. K., V., V., Rajan, A., and Zachariah, S. Mary, “Design, Synthesis, Characterization And In Vitro Evaluation Of Some Novel 3, 4-Dihydropyrimidine-2(1h)-One Derivatives For The Treatment Of Breast Carcinoma”, International Journal of Pharmaceutical Research, vol. 12, 2020.

Publisher : International Journal of Pharmaceutical Research

Year : 2020

Chemistry and Pharmacological Activities of Benzimidazole Derivatives – An Overview

Cite this Research Publication : V. V., R., R., P., M., V., S., N., A. P., and Zachariah, S. Mary, “Chemistry and Pharmacological Activities of Benzimidazole Derivatives - An Overview”, International Journal of Pharmaceutical Research, vol. 12, 2020.

Publisher : International Journal of Pharmaceutical Research

Year : 2020

In silico drug design of some novel compounds as an alternative for the anti IBD drugTofacitinib

Cite this Research Publication : V. V. and Dr. Subin Mary Zachariah, “In silico drug design of some novel compounds as an alternative for the anti IBD drugTofacitinib”, Research Journal of Chemistry and Environment, vol. 24, no. 8, pp. 11-17, 2020.

Publisher : Research Journal of Chemistry and Environment

Year : 2018

Chemistry And Pharmacological Activities Of Biginelli Product- A Brief Overview.

Cite this Research Publication : N. George, M Asokan, A., Ajish, A., Surya, S., Vishnu, V., Pai, R. G., and Dr. Subin Mary Zachariah, “Chemistry And Pharmacological Activities Of Biginelli Product- A Brief Overview.”, Curr Drug Discov Technol, 2018.

Publisher : Curr Drug Discov Technol

Year : 2017

In silico design, synthesis and characterization of some novel benzothiazole derivatives as anticancer agents

Cite this Research Publication : Dr. Leena K. Pappachen, Dr. Subin Mary Zachariah, and Chandran, D., “In silico design, synthesis and characterization of some novel benzothiazole derivatives as anticancer agents”, Asian Journal of Pharmaceutical and Clinical Research, vol. 10, pp. 150-155, 2017

Publisher : Asian Journal of Pharmaceutical and Clinical Research,

Year : 2017

In silico design, synthesis, characterization, in vitro anti-inflammatory, and antioxidant studies of 4-aryl-4H-chromene derivatives

Cite this Research Publication : J. Rajan, Krishnan, S., Menon, S. V., Dr. Subin Mary Zachariah, Pai, R. G., Surya, M., Javahar, M., and George, N., “In silico design, synthesis, characterization, in vitro anti-inflammatory, and antioxidant studies of 4-aryl-4H-chromene derivatives”, Asian Journal of Pharmaceutical and Clinical Research, vol. 10, pp. 408-413, 2017

Publisher : Asian Journal of Pharmaceutical and Clinical Research, Innovare Academics Sciences Pvt. Ltd

Year : 2017

Formulation and evaluation of novel chromene derivative as an anti-inflammatory agent used for inflammatory bowel diseases

Cite this Research Publication : K. Pa Reshmi, Dr. Subin Mary Zachariah, and Dr. Vidya Viswanad, “Formulation and evaluation of novel chromene derivative as an anti-inflammatory agent used for inflammatory bowel diseases”, Asian Journal of Pharmaceutical and Clinical Research, vol. 10, pp. 319-324, 2017

Publisher : Asian Journal of Pharmaceutical and Clinical Research

Year : 2016

An endogenous heterocyclic compound isatin

Cite this Research Publication : R. G. Pai, Surya, M., Javahar, P. B. Muhammed, Dr. Subin Mary Zachariah, and George, N., “An endogenous heterocyclic compound isatin”, Research Journal of Pharmaceutical, Biological and Chemical Sciences, vol. 7, pp. 107-120, 2016

Publisher : Research Journal of Pharmaceutical, Biological and Chemical Sciences.

Year : 2016

4-Aryl-4H-Chromene-3-Carbonitrile Derivates: Synthesis and Preliminary Anti-Breast Cancer Studies

Cite this Research Publication : Na Thomas, Dr. Subin Mary Zachariah, and Dr. Prasanna Ramani, “4-Aryl-4H-Chromene-3-Carbonitrile Derivates: Synthesis and Preliminary Anti-Breast Cancer Studies”, Journal of Heterocyclic Chemistry, vol. 53, no. 6, pp. 1778-1782, 2016.

Publisher : HeteroCorporation

Year : 2016

In silico design, synthesis, characterization and in vitro evaluation of some novel anti-lung cancer molecules

Cite this Research Publication : Dr. Subin Mary Zachariah, Ramkumar, M., George, N., Ashif, M. S., and Varghese, A., “In silico design, synthesis, characterization and in vitro evaluation of some novel anti-lung cancer molecules”, International Journal of Pharmacy and Technology, vol. 8, no. 1, pp. 11221-11235, 2016

Publisher : International Journal of Pharmacy and Technology

Year : 2015

In silico design , synthesis and invotro studies of some novel 4-phenyl 4H chromene derivatives as antioxidant and anti-inflammatory agents

Cite this Research Publication : Dr. Subin Mary Zachariah, Viswanad, V., KP, R., Viswanad, V., PS, N., SC, F. Beegum, and K., R. V., “In silico design , synthesis and invotro studies of some novel 4-phenyl 4H chromene derivatives as antioxidant and anti-inflammatory agents”, Journal of Chemistry and Pharmaceutical Research, vol. 7, no. 7, pp. 32-40., 2015.

Publisher : Journal of Chemistry and Pharmaceutical Research

Year : 2015

In silico design , synthesis and invotro studies of some novel 4-phenyl 4H chromene derivatives as antioxidant and anti-inflammatory agents

Cite this Research Publication : Dr. Subin Mary Zachariah, Viswanad, V., KP, R., Viswanad, V., PS, N., SC, F. Beegum, and K., R. V., “In silico design , synthesis and invotro studies of some novel 4-phenyl 4H chromene derivatives as antioxidant and anti-inflammatory agents”, Journal of Chemistry and Pharmaceutical Research, vol. 7, no. 7, pp. 32-40., 2015.

Publisher : Journal of Chemistry and Pharmaceutical Research

Year : 2015

A Review on Oxadiazole

Cite this Research Publication : Dr. Subin Mary Zachariah, Ramkumar, M., George, N., and Ashif, M., “A Review on Oxadiazole”, Research Journal of Pharmaceutical, Biological Chemical Sciences, vol. 6, no. 2, pp. 205-2019, 2015.

Publisher : Research Journal of Pharmaceutical, Biological Chemical Sciences

Year : 2015

Azetidinones: An overview

Cite this Research Publication : Dr. Subin Mary Zachariah, Ramkumar, M., ,, and Ashif, M., “Azetidinones: An overview”, International journal of Pharmaceutical Sciences, vol. 30, no. 1, pp. 211-218, 2015.

Publisher : International journal of Pharmaceutical Sciences

Year : 2014

Phytochemical Screening, Formulation and Evaluation of Dried Galls of Quercus Infectoria Oliv

Cite this Research Publication : Dr. Subin Mary Zachariah, Kumar, N. M., K, D., Gopal, D., Thomas, N., Ramkumar, M., and George, N., “Phytochemical Screening, Formulation and Evaluation of Dried Galls of Quercus Infectoria Oliv”, Int. J. Pharm. Sci. Rev. Res, 2014

Publisher : Int. J. Pharm. Sci. Rev. Res

Year : 2013

In Silico drug design and analysis of 4-Phenyl-4H-chromene derivatives as anticancer and anti-inflammatory agents

Cite this Research Publication : Dr. Subin Mary Zachariah and Thomas, N., “In Silico drug design and analysis of 4-Phenyl-4H-chromene derivatives as anticancer and anti-inflammatory agents”, International Journal of Pharmaceutical Sciences Review And Research, vol. 22, no. 2, pp. 50-54., 2013.

Publisher : International Journal of Pharmaceutical Sciences Review And Research

Year : 2013

Phytochemical and pharmacological activities of caesalpinia pulcherrima – An overview

Cite this Research Publication : V. Anju and Dr. Subin Mary Zachariah, “Phytochemical and pharmacological activities of caesalpinia pulcherrima - An overview”, International Journal of Pharmaceutical Research, vol. 5, pp. 6-13, 2013

Publisher : International Journal of Pharmaceutical Research

Year : 2013

Pharmacological activities of chromene derivatives: An overview

Cite this Research Publication : N. Thomas and Dr. Subin Mary Zachariah, “Pharmacological activities of chromene derivatives: An overview”, Asian Journal of Pharmaceutical and Clinical Research, vol. 6, pp. 11-15, 2013

Publisher : Asian Journal of Pharmaceutical and Clinical Research

Year : 2013

Monitoring the safety aspects of over the counter medications

Cite this Research Publication : Dr. Subin Mary Zachariah, Vidya, V., Halima, O. A., Geetu, G., and Devika, N., “Monitoring the safety aspects of over the counter medications”, IRJP, vol. 3, pp. 109–11, 2013.

Publisher : IRJP

Year : 2012

Free radical scavenging and antibacterial activity of Mirabilis jalapa Linn using in vitro models

Cite this Research Publication : Dr. Subin Mary Zachariah, Dr. Vidya Viswanad, Aleykutty, N. Ab, Jaykar, Bc, and Halima, O. Aa, “Free radical scavenging and antibacterial activity of Mirabilis jalapa Linn using in vitro models”, Asian Journal of Pharmaceutical and Clinical Research, vol. 5, pp. 115-120, 2012

Publisher : Asian Journal of Pharmaceutical and Clinical Research

Year : 2012

An overview on hepatoprotective activity of natural products

Cite this Research Publication : Dr. Subin Mary Zachariah, Aleykutty, Nb, Dr. Vidya Viswanad, and Halima, O. Aa, “An overview on hepatoprotective activity of natural products”, Research Journal of Pharmacy and Technology, vol. 5, pp. 317-321, 2012.

Publisher : Research Journal of Pharmacy and Technology

Year : 2012

In vitro anthelmintic activity of aerial parts of Mirabilis jalapa Linn

Cite this Research Publication : Dr. Subin Mary Zachariah, Aleykutty, N. Ab, Jayakar, Bc, Viswanad, Vac c, and Gopal, R. Va, “In vitro anthelmintic activity of aerial parts of Mirabilis jalapa Linn”, International Journal of Pharmaceutical Sciences Review and Research, vol. 12, pp. 107-110, 2012.

Publisher : International Journal of Pharmaceutical Sciences Review and Research

Year : 2012

Development and evaluation of antimicrobial herbal formulations containing the methanolic extract of Samadera indica for skin diseases

Cite this Research Publication : Vad Viswanad, Aleykutty, Nb, Jayakar, Bc, Dr. Subin Mary Zachariah, and Thomas, Lc, “Development and evaluation of antimicrobial herbal formulations containing the methanolic extract of Samadera indica for skin diseases”, Journal of Advanced Pharmaceutical Technology and Research, vol. 3, pp. 106-111, 2012

Publisher : Journal of Advanced Pharmaceutical Technology and Research

Year : 2012

Evaluation of Antibacterial and Total Flavanoid Content of Mirabilis Jalapa Using Invitromodels

Cite this Research Publication : S. Mary Zachariah, N.A, D. Aleykutty, Vidya,, Viswanad,, and O.A., H., “Evaluation of Antibacterial and Total Flavanoid Content of Mirabilis Jalapa Using Invitromodels”, International Research Journal of Pharmacy, vol. 3, 3 vol., pp. 187-192, 2012.

Publisher : International Research Journal of Pharmacy

Year : 2012

Evaluation of Antioxidant and Total Flavanoid Content of Mirabilis Jalapa using InVitro Models

Cite this Research Publication : Dr. Subin Mary Zachariah, A, D. Aleykutty, Viswanad, V., and A, H. O., “Evaluation of Antioxidant and Total Flavanoid Content of Mirabilis Jalapa using InVitro Models”, International Research Journal of Pharmacy, no. 3, pp. 187-191. , 2012.

Publisher : International Research Journal of Pharmacy

Year : 2011

In-vitro Antioxidant Potential of Methanolic Extracts of Mirabilis jalapa Linn

Cite this Research Publication : Dr. Subin Mary Zachariah, Aleykutty, N. A., Viswanad, V., Jacob, S., and Prabhakar, V., “In-vitro Antioxidant Potential of Methanolic Extracts of Mirabilis jalapa Linn”, Free Radicals and Antioxidants, vol. 1, pp. 82 - 86, 2011.

Publisher : Free Radicals and Antioxidants

Year : 2011

Antimicrobial Potential of Herbal Medicines

Cite this Research Publication : Dr. Subin Mary Zachariah, Viswanad, V., Aleykutty, D. N. A., and Prabhakar, V., “Antimicrobial Potential of Herbal Medicines”, International Journal of Pharmaceutical Sciences & Research. , vol. 2, no. 7, pp. 1651-1658. , 2011

Publisher : International Journal of Pharmaceutical Sciences & Research.

Year : 2011

Studies on the Antimicrobial and Antioxidant Activities of the Methanolic Extracts of Samadera Indica

Cite this Research Publication : Vac Viswanad, Aleykutty, N. Ab, Jaykar, Bc, Dr. Subin Mary Zachariah, and Thomas, La, “Studies on the Antimicrobial and Antioxidant Activities of the Methanolic Extracts of Samadera Indica”, International Journal of Pharmaceutical Sciences Review and Research, vol. 11, pp. 59-64, 2011

Publisher : International Journal of Pharmaceutical Sciences Review and Research

Year : 2011

Evaluation of antioxidant and free radical scavenging activity of Samadera indica using In vitro models

Cite this Research Publication : Dr. Vidya Viswanad, Aleykutty, N. Ab, Dr. Subin Mary Zachariah, and Thomas, La, “Evaluation of antioxidant and free radical scavenging activity of Samadera indica using In vitro models”, Pharmacognosy Journal, vol. 3, pp. 85-90, 2011

Publisher : Pharmacognosy Journal

Year : 2010

Phytochemical screening and anti inflammatory, bronchodilator and antimicrobial activities of the seeds of i xmlns=http://www.w3.org/1999/xhtmlLuffa cylindrica/i.

Cite this Research Publication : P. Muthumani, Meera, R., Dr. Subin Mary Zachariah, ,, Devi, P., Kameswari, B., and Priya, B. E., “Phytochemical screening and anti inflammatory, bronchodilator and antimicrobial activities of the seeds of Luffa cylindrica.”, Research Journal of Pharmaceutical, Biological and Chemical Sciences, vol. 1, pp. 11-22, 2010.

Publisher : Research Journal of Pharmaceutical, Biological and Chemical Sciences

Year : 2010

Phytochemical And Pharmacological Screening Of Sphaeranthus Indicus Linn. For Antimicrobial Activity

Cite this Research Publication : Dr. Subin Mary Zachariah, Dr. Leena K. Pappachen, Dr. Aneesh T. P., Alex, L., Sumith, G., John, M. Sheeba, Praseetha, M. C., and Nagalekshmi, R., “Phytochemical And Pharmacological Screening Of Sphaeranthus Indicus Linn. For Antimicrobial Activity”, International Journal of Pharmaceutical Sciences and Research, vol. 1, pp. 169-173, 2010

Publisher : International Journal of Pharmaceutical Sciences and Research

Year : 2010

Phytochemical screening and anti inflammatory, bronchodilator and antimicrobial activities of the seeds of Luffa cylindrica.

Cite this Research Publication : P. Muthumani, Meera, R., Dr. Subin Mary Zachariah, ,, Devi, P., Kameswari, B., and Priya, B. E., “Phytochemical screening and anti inflammatory, bronchodilator and antimicrobial activities of the seeds of Luffa cylindrica.”, Research Journal of Pharmaceutical, Biological and Chemical Sciences, vol. 1, pp. 11-22, 2010

Year : 2009

A study of genetic engineering techniques in biotechnology based pharmaceuticals

Cite this Research Publication : Dr. Subin Mary Zachariah and Dr. Leena K. Pappachen, “A study of genetic engineering techniques in biotechnology based pharmaceuticals”, The Internet Journal,Nanotechnology, vol. 3, no. 1, pp. 1 - 8, 2009.

Publisher : The Internet Journal,Nanotechnology

Year : 2009

Combinatorial Drug Design-Formulation of the Era

Cite this Research Publication :
Dr. Leena K. Pappachen, Dr. Subin Mary Zachariah, and Fasmi;, K. N., “Combinatorial Drug Design- formulation of the Era.”, Int.Jour.Chem.Sci., 2009.

Publisher : International Journal of Chemical Science

Year : 2009

Combinatorial Drug Design- formulation of the Era.

Cite this Research Publication : Dr. Leena K. Pappachen, Dr. Subin Mary Zachariah, and Fasmi;, K. N., “Combinatorial Drug Design- formulation of the Era.”, Int.Jour.Chem.Sci., 2009.

Publisher : Int.Jour.Chem.Sci.

Year : 2009

Radio Frequency Identification: An Effective Tool to Prevent Drug Counterfeiting

Cite this Research Publication : Dr. Aneesh T. P., M, S. Sekhar, P.O, S., Dr. Sabitha M., and Dr. Subin Mary Zachariah, “Radio Frequency Identification: An Effective Tool to Prevent Drug Counterfeiting”, Journal of Pharmacy Research, vol. 2, no. 4, pp. 678 - 679, 2009.

Publisher : Journal of Pharmacy Research

Year : 2009

Phytochemistry and Antimicrobial Screening of Stem Bark of Murraya Koenigii (Linn) Spreng

Cite this Research Publication : Dr. Subin Mary Zachariah, Muthumani, P., and Ramaseshu, K., “Phytochemistry and Antimicrobial Screening of Stem Bark of Murraya Koenigii (Linn) Spreng”, The Internet Journal of Pharmacology. , vol. 6, no. 2, 2009.

Publisher : The Internet Journal of Pharmacology.

Year : 2009

Pharmacogenomics: The Right Drug to the Right Person.

Cite this Research Publication : Dr. Aneesh T. P., Sekhar, S., Asha, A., Chandran, L., and Zachariah, S. Mary, “Pharmacogenomics: The Right Drug To The Right Person”, Journal of clinical medicine research, pp. 191–194, 2009

Publisher : Journal of Clinical Medicine Research.

Conference Paper

Year : 2018

Synthesis, Antioxidant and Anti-inflammatory Studies of Substituted Chromene – A Preliminary Anti-Cancer study

Cite this Research Publication : cited By 0; Conference of 2016 International Conference on Advanced Materials, SCICON 2016 ; Conference Date: 19 December 2016 Through 21 December 2016; Conference Code:138807

Publisher : Elsevier Ltd

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