Two primary research directions of the group are:
- Immune Regulation of Cardiac RegenerationInjury in an adult heart leads to the loss of functional cardiomyocytes (the beating cells). The loss of cells triggers an immune response, which regulates the regenerative response. As human heart doesn’t have robust regenerative ability, and thus heals primarily by forming non-functional scar tissue (fibrosis). We understand, how immune response following an injury modulates regeneration (formation of new functional cardiomyocytes) vs. fibrosis.
- Molecular Regulators of Cardiac CalcificationAging, injury, and metabolic diseases can lead to calcification in the cardiovascular system. Calcification is the abnormal deposition of a bony matrix in soft tissue that can cause a mechanical or electrical block in the conduction system of the heart. The blockage can disrupt the smooth propagation of electric impulses leading to arrhythmias.